核心實驗室成員


喻秋華 博士/國家衛生研究院 分子與基因醫學研究所 研究員

游美淑 博士/國家衛生研究院 分子與基因醫學研究所 高級技術師

江運金 博士/國家衛生研究院 分子與基因醫學研究所 副研究員

English CV


Dr. Yuh, Chiou-Hwa
Dr. Yuh, Chiou-Hwa/Investigator at Institute of Molecular and Genomic Medicine, National Health Research Institutes

喻秋華 博士/國家衛生研究院分子與基因醫學研究所研究員

喻秋華博士於1992年在Dr. Ting, Ling-Pai的指導下於陽明大學微生物及免疫研究所取得博士學位,並於1992年到2004年間在Dr. Eric Davidson的指導下於美國加州理工大學進行博士後研究。擔任博士後研究期間,參加了Endo16基因的轉錄調控的解碼,並且發表的第一篇使用電腦理論來解釋轉錄調控的生物資訊論文。同時也參與建立海膽胚胎的內胚層有關的基因調控網路,Dr. Eric Davidson實驗室成功的建立了第一個很好的網路模型。由於喻博士在蛋白質純化和定序有很豐富的經驗,在2001年到2002年喻博士擔任了the Transcription Factor Center of Beckman Institute at California Institute of Technology的負責人。喻博士總共發表了14篇有高度影響的論文,其中兩篇發表在Science。在2004年12月31日,喻博士回到國衛院分基組任職,並開始使用斑馬魚作為模式生物來解碼胚胎基因調控網絡。利用GRN建模工具(BioTapestry)喻博士建立了斑馬魚的內胚層及中胚層基因調控網絡的模型,通過系統方法功能解剖內胚層的重要子電路,並在國際知名期刊上,如發育生物學、BMC發育生物學發表六篇論文。對於轉譯研究,喻博士發現癌症的發生與發育相關的基因和信號通路被錯誤表現有密切關係。喻博士開始利用小鼠肝癌模型作系統分析,從小鼠模型找出五大關鍵致癌基因,並建立轉基因斑馬魚模型。喻博士已利用人類肝癌標本驗證,並利用轉基因斑馬魚的證實五大關鍵致癌基因與肝癌的關係。對於應用,喻博士的進一步發展藥物篩選平台,篩選新的可有效地治療肝癌的小分子藥物,並具有比Sorafenib較低的毒性。喻博士共撰寫過43的研究和回溯性論文,包括科學,PNAS,發育生物,發育生物學,國際癌症雜誌,並發表了3本書的章節。

Dr. You, May-Su/Senior Specialist at Institute of Molecular and Genomic Medicine, National Health Research Institutes
Dr. You, May-Su/Senior Specialist at Institute of Molecular and Genomic Medicine, National Health Research Institutes

游美淑 博士/國家衛生研究院分子與基因醫學研究所高級技術師

游美淑博士於2001在德國, Stuttgart Institute for Biological Chemistry and Nutrition, Hohenheim University得到博士學位。2003年到2008年擔任 Institute of Molecular and Cell Biology, Singapore (IMCB) 斑馬魚核心設施經理一職,於2008年10月到國衛院任職。IMCB斑馬魚核心設施是由她規劃而設立,在她5年多的經營及管理中,分別製訂了魚房運作及管理的各種標準操作手冊(SOP)、魚缸的coding系統及建立斑馬魚精子冷凍和人工受精(in vitro fertilization)的技術。在豐富經驗的Dr. 游的管理之下,台灣斑馬魚核心設施的國衛院分支於2015年3月19日通過AAALAC International的認証。我們相信台灣斑馬魚核心設施將會是一個符合世界水準的國家級設施。

Dr. Jiang, Yun-Jin

Dr. Jiang, Yun-Jin/Associate Investigator at Institute of Molecular and Genomic Medicine, National Health Research Institutes

江運金 博士/國家衛生研究院分子與基因醫學研究所副研究員

江運金博士於1997年在諾貝爾學家Dr. Christiane Nusslein-Volhard的指導下取得生物學博士學位,博士論文題目是:Genetic Analysis of Early Neural Development in the Zebrafish, Danio rerio。他在諾貝爾學家Dr. Christiane Nusslein-Volhard的實驗室受訓成斑馬魚生物學家。期間,江博士參加了世界第一個大型斑馬魚篩選計畫,而這個計畫產生了許多有用的突變魚種。1997年到2001年在英國Vertebrate Development Laboratory, Imperial Cancer Research Fund, London/UK (Dr. Julian Lewis’s Lab)擔任博士後研究一職。2001年在新加坡的Laboratory of Developmental Signaling and Patterning in the Institute of Molecular and Cell Biology擔任研究員。到目前為止,江博士已經發表了許多有關斑馬魚的論文。

 

English CV

Dr. Yuh, Chiou-HwaInvestigator at Institute of Molecular and Genomic Medicine, National Health Research Institutes

Dr. Chiou-Hwa (Cathy) Yuh is currently an Investigator at National Health Research Institutes and Associate Professor at National Tsing-Hua University and National Chiao Tung University. Dr. Yuh received her B.A. from Biology Division at Fu-Jen Catholic University, Taiwan in 1987, and received her Ph.D. from Institute of Microbiology and Immunology at National Yang-Ming Medical College, Taiwan in 1992. Dr. Yuh received the postdoc training at Biology Division in California Institutes of Technology starting 1992, under the direction of Dr. Eric Davidson. She decoded the regulatory circuit of endoderm specific gene in sea urchin, Endo16 and published the paper in Science on 1998, using computational algorisms to explain the transcription regulation. Dr. Yuh gained tremendous experience on the systematic approached of embryonic development and GRNs. Seventeen scientific high impact papers and three book chapters were published before she joined NHRI.

Dr. Yuh was recruited as an Associate Investigator by the DMGM of NHRI at December 31 of 2004, and started using zebrafish as model organism to decode the embryonic gene regulatory networks. Using a web-enabled GRN modeling tool (BioTapestry) to build an integrated model of the Endomesoderm Gene Regulatory Network in zebrafish, functional dissecting the important subcircuits in the endoderm networks by systematically approaches, she identified several interesting functional motifs that are important building blocks in zebrafish developmental GRNs, and published six papers on international well known journals such as Developmental Biology, BMC Developmental Biology and Birth Defects Research Part C. For the translational research, Dr. Yuh had found the genes and pathways in development were dysregulated in cancer. She initiated the systematic analysis of hepatocellular carcinoma (HCC) in mouse model, and established transgenic zebrafish model. Dr. Yuh has identified five critical oncogenes from mouse model, verified using human HCC specimens, and confirmed in transgenic zebrafish. For application, Dr. Yuh’s further develops the drug screening platform to identified novel small molecules which are effective in treatment HCC and lower toxicity compared to Sorafenib. Dr. Yuh has authored over 43 research and review papers in peer-reviewed professional journals including Science, PNAS, Development, Carcinogenesis and International Journal of Cancer, and contributed to 3 book chapters.

 

Dr. You, May-SuSenior Specialist at Institute of Molecular and Genomic Medicine, National Health Research Institutes

Dr. May-Su You is currently a Senior Specialist in The Institute of Molecular and Genomic Medicine of National Health Research Institutes. She received her BSc in Human Nutrition from Taipei Medical University, Taiwan and her Ph.D. from Institut fur Biologische Chemie und Ernahrungswissenschaft (Institute of Biological Chemistry and Nutrition Sciences), Universitat Hohenheim, Stuttgart, Germany. After one year postdoc training in the Lab of Fish Developmental Biology in the Institute of Molecular and Cell Biology, Singapore, Dr, You became the manager of Zebrafish Core Facility in IMCB in 2003. She established an 8000 tanks containing zebrafish facility from scratch and managed the facility with bio-coding system and SOPs. She initiated the zebrafish IACUC form in IMCB and provided services to all scientists within Biopolis, Singapore. Dr. You was recruited by the IMGM of NHRI as a Senior Specialist in 2008 to establish a zebrafish core facility for NHRI and NTHU. This joint core facility has become a National Zebrafish Core Facility from 2010 with NSC (National Science Council) grant support.

Under the management of Dr. You, the zebrafish facility of NHRI becomes an AAALAC International accredited facility in March 2015. Dr You’s expertise is in zebrafish husbandry, facility set-up and management. She is also actively involved in establishing platforms for biomedical research using zebrafish as a disease model, for example, toxicity test and behavior analysis.

Dr. Jiang, Yun-JinAssociate Investigator at Institute of Molecular and Genomic Medicine, National Health Research Institutes

Dr. Yun-Jin Jiang is currently an Associate Investigator in the Institute of Molecular and Genomic Medicine (IMGM), National Health Research Institutes (NHRI), Taiwan and an Adjunct Associate Professor in the National Taiwan University, Taipei and a Joint Associate Professor in the National Chung Hsing University, Taichung. Dr. Jiang received his BSc from the Department of Agricultural Chemistry, National Taiwan University in 1986 and MSc from the Institute of Biochemical Sciences, National Taiwan University in 1988. After two years’ military service as an Armor Second Lieutenant in the Taiwanese Army and two years employment as a Research Assistant in the Institute of Molecular Biology, Academia Sinica, Taipei, he went to Germany and earned his PhD from the Fakultat fur Biologie of Eberhard-Karls Universitat (Tubingen University) and worked in the laboratory of Frau Professor Dr. Christiane Nusslein-Volhard, in the Max-Planck-Institut fur Entwicklungsbiologie, Abteilung Genetik, Tubingen, Germany in 1997. He worked with other scientists in the first large-scale zebrafish screen during his PhD study. He carried out his postdoctoral training in the Laboratory of Dr. Julian Lewis in the Imperial Cancer Research Fund, London, UK, where he characterized the somite mutants and demonstrated that Notch signaling is essential for somite segmentation. In 2001, Dr. Jiang assumed his duty as a Senior Scientist in the Institute of Molecular and Cell, A*STAR, Singapore and further explored the functions of Notch signaling in zebrafish development. At the same time, he was an Adjunct Assistant Professor in the Department of Biochemistry, National University of Singapore, Singapore from 2003 and became an Adjunct Associate Professor in 2008. Dr. Jiang was recruited to IMGM/NHRI in 2009 and continued his work in studying signal transduction and vertebrate development by using zebrafish as a model. His recent interest is to use zebrafish model to explore human diseases, e.g. cancer and Alzheimer’s disease.

Dr. Jiang has authored more that 62 original research and review papers on topics including large-scale zebrafish genetic screen, zebrafish development, Notch signaling, somitogenesis, neurogenesis, hematopoiesis and functions of novel genes in relation to Notch signaling and DNA replication. These papers were published in journals including Nature, Developmental Cell, Trends in Cell Biology, Blood, Current Biology, Circulation Research, Oncogene, PLoS Genetics, Development, Molecular Biology of the Cell, BMC Genomics. In addition, he has written 4 book chapters. The h-index of his published work is 37.

 

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